On December 31, 2018, Natera, Inc. entered into an amendment and waiver to its credit agreement dated August 8, 2017 with OrbiMed Royalty Opportunities II, L.P. The Credit Agreement provides for a $100,000,000 senior secured term loan facility, of which $75,000,000 was provided to Natera in August 2017 and the remaining $25,000,000 was to be provided at Natera’s request no later than December 31, 2018. The Amendment increased the amount of the Delayed Draw to $50,000,000 and extended the deadline for the Delayed Draw to March 31, 2019. Upon the Delayed Draw, if any, the interest rate for the Loans will decrease to the sum of (i) 8.50% plus (ii) the higher of (x) the LIBO Rate for such Interest Period and (y) 1.00.