Exact Sciences : SASB Index for the FY ended 12/30/2023

EXACT SCIENCES 2023 SUSTAINABILITY ACCOUNTING STANDARDS BOARD (SASB) INDEX

These tables provide data and information using the SASB Health Care Delivery standard, which we believe best represents the nature of Exact Sciences' operations. We also include indicators from the Biotechnology and Pharmaceuticals standard. The data represents full-year 2023 performance.

Category	Code	Accounting Metric	Information
Energy		(1) Total energy consumed, (2) percentage grid electricity,	(1)	32,154,754 kWh of electricity, 767,784 therms of natural gas
HC-DY-130a.1	(2)	59%
Management	(3) percentage renewable
	(3)	0%
			39 U.S. tons of medical waste
		Total amount of medical waste, percentage (a) incinerated,	(a)	31%
	HC-DY-150a.1	(b)	0%
	(b) recycled or treated, and (c) landfilled	(c)	69%
			For details, see: Waste Management in our 2023 ESG Report
			(1) 101 U.S. tons of hazardous waste
Waste			(a)	81%
Management			(b)	11%
		Total amount of (1) hazardous and (2) nonhazardous	(c)	8%
	HC-DY-150a.2
	pharmaceutical waste, percentage	(2) 4,818 U.S. tons of nonhazardous waste
		(a) incinerated, (b) recycled or treated, and (c) landfilled	(a)	7%
			(b)	45%
			(c)	47%
			For details, see: Waste Management in our 2023 ESG Report
		Percentage of patient records that are Electronic Health	Not reported
	HC-DY-230a.1	For details, see: Cybersecurity, Privacy & Data Protection in our 2023 ESG Report
	Records (EHR) that meet "meaningful use" requirements
Patient Privacy &
Electronic Health			We have technical, administrative, and physical safeguards in place to help protect
Records		Description of policies and practices to secure customers'
	HC-DY-230a.2	against unauthorized access to, use, or disclosure of patient and employee
	protected health information (PHI) records and other	information and data we collect and store.
		personally identifiable information (PII)	For details, see: Cybersecurity, Privacy & Data Protection in our 2023 ESG Report

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EXACT SCIENCES 2023 SUSTAINABILITY ACCOUNTING STANDARDS BOARD (SASB) INDEX

Category	Code	Accounting Metric	Information
		(1) Number of data breaches, (2) percentage	Not reported
Patient Privacy &	HC-DY-230a.3	involving (a) personally identifiable information (PII) only and (b)
protected health information (PHI), (3) number of customers	For details, see: Cybersecurity, Privacy & Data Protection in our 2023 ESG Report
Electronic Health		affected in each category, (a) PII only and (b) PHI2
Records
HC-DY-230a.4	Total amount of monetary losses as a result of legal	Material legal, regulatory, and monetary issues are disclosed in our annual 10-K and
	proceedings associated with data security and privacy	quarterly 10-Qs.
			Exact Sciences takes every viable step to make testing available, accessible, and
		Discussion of strategy to manage the mix of patient insurance	affordable, and we offer financial assistance programs for eligible patients with
	HC-DY-240a.1	financial hardship.
Accessfor Low-	status
		For details, see: Access to Tests in our 2023 ESG Report
Income Patients
	HC-DY-240a.2	Amount of Medicare Disproportionate Share Hospital (DSH)	Not applicable - Exact Sciences provides laboratory testing services
	adjustment payments received
	HC-DY-250a.1	Average Hospital Value-Based Purchasing Total Performance	Not applicable - Exact Sciences provides laboratory testing services
	Score and domain score, across all facilities
	HC-DY-250a.2	Number of Serious Reportable Events (SREs) as defined by the	Not reported
	National Quality Forum (NQF)
Quality of Care &
Patient	HC-DY-250a.3	Hospital-Acquired Condition (HAC) Score per Hospital	Not applicable - Exact Sciences provides laboratory testing services
Satisfaction
HC-DY-250a.4	Excess readmission ratio per hospital	Not applicable - Exact Sciences provides laboratory testing services
	HC-DY-250a.5	Magnitude of readmissions payment adjustment as part of the	Not applicable - Exact Sciences provides laboratory testing services
	Hospital Readmissions Reduction Program (HRRP)
	HC-DY-260a.1	Description of policies and practices to manage the number of	Not applicable - Exact Sciences provides laboratory testing services
Management of	prescriptions issued for controlled substances
Controlled
	Percentage of controlled substance prescriptions written for
Substances	HC-DY-260a.2	Not applicable - Exact Sciences provides laboratory testing services
	which a prescription drug monitoring program (PDMP) database
		was queried
Pricing & Billing	HC-DY-270a.1	Description of policies or initiatives to ensure that patients are	Not applicable - Exact Sciences provides laboratory testing servicesĂ
Transparency	adequately informed about price before undergoing a procedure	For details, see: Access to Health Care in our 2023 ESG Report

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EXACT SCIENCES 2023 SUSTAINABILITY ACCOUNTING STANDARDS BOARD (SASB) INDEX

Category	Code	Accounting Metric	Information
			We have a Patient Support Team providing informational resources to
		Discussion of how pricing information for services is made	patients who have questions about our products and services, including
	HC-DY-270a.2	insurance coverage
	publicly available
Pricing & Billing
		For details, see: Access to Tests in our 2023 ESG Report
Transparency
	Number of the entity's 25 most common services for which
	HC-DY-270a.3	pricing information is publicly available, percentage of total	Not reported
		services performed (by volume) that these represent
Employee Health &	HC-DY-320a.1	(1) Total recordable incident rate (TRIR) and (2) days away,	(1)	0.49 per 200,000 hours worked
Safety		restricted, or transferred (DART) Rate	(2)	0.33
		(1) Voluntary and (2) involuntary turnover rate for: (a)	(a) Not applicable - Exact Sciences does not employ physicians.
		(b) Not applicable - Exact Sciences does not employ health care
	HC-DY-330a.1	physicians, (b) non-physician health care practitioners, and (c) all
		other employees		practitioners.
Employee		(c) Voluntary: 8.4%, involuntary: 4.6%
Recruitment,			We are committed to providing safe and healthy work environments for
Development &			our employees, where equal opportunity and diversity in thought,
Retention	HC-DY-330a.2	Description of talent recruitment and retention efforts for	experience, perspective, and background are commonplace. Note, we do
	HC-BP-330a.1	health care practitioners	not employ health care practitioners.
			For details, see: Human Capital in our 2023 ESG Report
		Description of policies and practices to address: (1) the physical
	HC-DY-450a.1	risks due to an increased frequency and intensity of extreme	For details, see: TCFD Index in our 2023 ESG Report
Climate Change	weather events and (2) changes in the morbidity and mortality
Impacts on		rates of illnesses and diseases, associated with climate change
Human Health &
Infrastructure		Percentage of health care facilities that comply with the Centers
	HC-DY-450a.2	for Medicare and Medicaid Services (CMS) Emergency	Not applicable - Exact Sciences provides laboratory testing services.
		Preparedness Rule
Fraud &		Total amount of monetary losses as a result of legal	Material legal and regulatory issues are disclosed in our annual 10-K
Unnecessary	HC-DY-510a.1	proceedings associated with Medicare and Medicaid fraud
and quarterly 10-Qs.
Procedures		under the False Claims Act

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EXACT SCIENCES 2023 SUSTAINABILITY ACCOUNTING STANDARDS BOARD (SASB) INDEX

Category

Code	Accounting Metric

Information

			Employees involved in sales and marketing receive regular compliance training on the
			laws, regulations, and codes that govern interactions with physicians and other
	HC-BP-270a.2	Description of code of ethics governing promotion of off-label	customers, on the promotion of our products, and on our Code of Business Conduct and
	use of products	Ethics.
Ethics
		For details, see Business Ethics in our 2023 ESG Report
	HC-BP-510a.2	Description of code of ethics governing interactions with health	See ourCode of Conduct on Interactions with Health Care Professionals
	care professionals
			We design and conduct all clinical studies in accordance with the general principles set
			forth in the International Ethical Guidelines for Biomedical Research Involving Human
Safety of Clinical	HC-BP-210a.1	Discussion, by world region, of management process for ensuring	Subjects (by the Council for International Organizations for Medical Sciences), USFDA
Trial Participants	quality and patient safety during clinical trials	Title 21 CRF §11, 50, 54, 56, 812, & 814, the Declaration of Helsinki (World Medical
	Association), and ICH GCP E6.
			For details, see: Clinical Research Programs & Standards in our 2023 ESG Report
	HC-DY-000.A	Number of (1) facilities and (2) beds, by type	Not applicable - Exact Sciences provides laboratory testing services.
	HC-DY-000.B	Number of (1) inpatient admissions and (2) outpatient visits	Not applicable - Exact Sciences provides laboratory testing services.
			As of 2023, we screened more than 14 million patients with Cologuard and tested
Activity Metrics	HC-BP-000.A	Number of patients treated	nearly 1.3 million patients with Oncotype.
For details, see: Taking Care of the People We Serve in our 2023 ESG Report
			Not applicable - Exact Sciences provides laboratory testing services.
	HC-BP-000.B	Number of drugs (1) in portfolio and (2) in research and	(1)	See Our Testson our website to learn more.
	development (Phases 1-3)
			(2)	See Our Pipeline & Dataon our website to learn more.

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