This state-of-the-art solution revolutionizes the field of predictive biomarker research and drug development. The best-in-class multiomics solution leverages ACD's RNAscope HiPlex RNA detection and Lunaphore's universal multiplex sequential immunofluorescence (seqIF) technology on the COMET platform, which performs protein detection with standard, non-conjugated antibodies. The multiomics application will be commercially available in Q2 2024.
Until now, researchers have faced challenges in integrating critical spatial information and accessing true multi-modal, same-cell analysis with full workflow automation. The Company's new multiomics solution for translational research overcomes this gap by enabling the correlation of RNA and protein data at the subcellular level in its spatial tissue context without any user intervention and with the highest throughput in the hyperplex market. This fully automated workflow enables researchers and clinicians to generate highly robust data through reliable and reproducible target detection. It offers complete flexibility in panel design by selecting any protein target with the use of standard reagents, including clinically proven IHC antibodies and RNAscope.
'Combining ACD's leading RNA detection technology with Lunaphore's fully automated high-throughput protein detection capabilities on the COMET system enables a best-in-class multiomics spatial biology solution,' commented
The complete multiomics solution will be showcased through a series of activities at the Lunaphore Suite,
About
About COMET
COMET is the only fully automated, high-throughput, hyperplex platform ensuring scalability and reproducibility without the need to conjugate primary antibodies. COMET provides walk-away automation, integrating staining, imaging, and image preprocessing steps to obtain standard hyperplex images. The multiomics capability of COMET enables the simultaneous analysis of both RNA and protein data within the spatial context of tissues to enhance the understanding of cellular dynamics and disease processes. COMET generates highly robust and reproducible data with full tissue preservation, allowing researchers to perform downstream modalities such as H&E or transcriptomics using the same slide. Its superior tissue profiling capabilities facilitate the analysis of 40 different spatial markers in each automated run on a tissue slide. In contrast to other spatial biology solutions, COMET works with off-the-shelf, label-free primary antibodies, making panel design much more flexible and faster than any other hyperplex solution. COMET works with regular glass slides from standard histology workflows; it is validated for human and mouse samples and is compatible with any other animal sample. The platform can be used for a wide range of research applications, allowing for a dramatic improvement in the understanding of disease pathology.
Contact:
Email: communications@lunaphore.com
Email: david.clair@bio-techne.com
Tel: 612-656-4416
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