Effective as of the close of business on April 30, 2024, Henry Hagopian is no longer serving as the principal financial officer of Annovis Bio, Inc. (the Company). Mr. Hagopian is stepping down from this position to pursue other opportunities. Mr. Hagopian?s resignation was not due to any disagreement or dispute with the Company or the Board of Directors of the Company regarding any matter, including the Company?s accounting principles, practices, financial statement disclosures or compliance procedures.

On May 1, 2024, the Board appointed Maria Maccecchini, the Company?s President and Chief Executive Officer, as the interim principal financial officer, effective immediately, in light of Mr. Hagopian?s departure.