Effective January 13, 2017, Bacterin International, Inc. (Bacterin) and wholly-owned subsidiary of Xtant Medical Holdings, Inc., as borrower, the company, X-Spine Systems, Inc. and wholly-owned subsidiary of the company, and Xtant Medical, Inc. and wholly-owned subsidiary of the company, collectively as the guarantors, ROS Acquisition Offshore LP (ROS) and OrbiMed Royalty Opportunities II, LP (OrbiMed), entered into the Eighth Amendment to Amended and Restated Credit Agreement, which amended the existing Amended and Restated Credit Agreement. The Facility generally provided for the refinancing of approximately $24,000,000 in previously existing term loans and the borrowing of an additional $18,000,000 by Bacterin.