Certain Options of Xenon Pharmaceuticals Inc. are subject to a Lock-Up Agreement Ending on 3-JAN-2022. These Options will be under lockup for 90 days starting from 5-OCT-2021 to 3-JAN-2022. Details: The executive officers and directors have agreed that they will not offer, sell, contract to sell, pledge or otherwise dispose of, directly or indirectly, any shares of common stock or securities convertible into or exchangeable or exercisable for any shares of common stock, for a period of 60 days after the date of the final prospectus supplement without the prior written consent of Leerink Partners LLC.