Waters Corporation introduced a new cation exchange column line with specialized consumables to simplify and improve the characterization and monitoring of monoclonal antibody (mAb) therapeutics. The new BioResolve™ SCX mAb Columns and Vanguard™ FIT Cartridge technologies, together with a suite of complementary consumables, enable mAb charge-variant analyses as required by the World Health Organization, the U.S. Food and Drug Administration, and the International Conference on Harmonization for confirming the efficacy and safety of biologics and biosimilars within discovery, development, and manufacturing applications. BioResolve SCX mAb Columns contain an innovative strong-cation exchanger based on a novel polymeric composition, hydrophilic coating and multi-component surface chemistry all synthesized at Waters chemistry manufacturing facility. The base material consists of three-micron non-porous particles for optimal diffusion kinetics, high pressure capability and compatibility with HPLC, UHPLC and UPLC™ methods. The columns are also available with a first–of-its-kind Vanguard Fully Integrated Technology (FIT) Cartridge which prevents particulates and other contaminants from being carried onto the column thereby extending its working life and reducing the cost-per-analysis without compromising the quality of the separation. Each batch of material for the BioResolve SCX mAb columns and VanGuard FIT cartridges are specifically quality control-tested with a new and commercially-available mAb charge variant standard derived from the National Institute of Science and Technology Reference Material 8671 (i.e. humanized IgG1?) to help ensure batch-to-batch consistency of the new offering.