On March 18, 2019, Tyme Technologies, Inc. announced the departure of Michael Demurjian as Executive Vice President, Chief Operating Officer and director of the Company. Michael Demurjian gave notice of resignation from employment and the Board of Directors on March 15, 2019, effective that same day. Also on March 15, 2019, the Board approved the appointment of Michele Korfin, the Company's current Chief Commercial Officer, as the Company's Chief Operating Officer, and approved the appointment of Dr. Jonathan Eckard, the Company's current Chief Scientific Affairs Officer, as the Company's Chief Business Officer, each effective March 15, 2019. Prior to this appointment, Ms. Korfin, age 47, has served as the Company's Chief Commercial Officer since October 9, 2018. Prior to this appointment, Dr. Eckard, age 44, has served as the Chief Scientific Affairs Officer of Tyme since August 2017.