Shuttle Pharmaceuticals Holdings, Inc. announced the publication of a manuscript discussing immune responses taking place in patients after radiation therapy for cancer. The manuscript, titled, "Radiation therapy induces innate immune responses in patients treated for prostate cancer. Radiation therapy (RT) is a curative therapeutic modality used to treat cancers as a single agent or in combination with surgery and chemotherapy.

To understand systemic clinical responses after radiation exposure, proteomic and metabolomic analyses were performed on plasma obtained from cancer patients at intervals after prostate radiation therapy. DNA Damage Response (DDR) increased within the first hour after treatment and returned to baseline by one month. Robust immune signaling also increased within one hour of treatment but persisted for up to three months thereafter.

The data support innate immune activation as a critical clinical response of patients receiving radiation therapy for prostate cancer, potentially informing multidisciplinary therapeutic strategies for cancer treatment. The study was supported by NIH SBIR Contracts to Shuttle Pharmaceuticals, Inc. which were subcontracted from Shuttle Pharmaceuticals, Inc. to Georgetown University.