WuXi NextCODE announced a partnership with Rhythm Pharmaceuticals, under which Rhythm is applying WuXi NextCODE's proprietary deep learning capabilities to identify key genetic markers for rare metabolic syndromes. The goal is to use that information to optimize the development of Rhythm's investigational compounds. Financial terms were not disclosed. The first phase of the partnership involved mining WuXi NextCODE's knowledgebase of all major reference datasets to identify all rare sequence variants in the POMC, PCSK1, and LEPR genes in the MC4R pathway. This is a key biological pathway in humans that regulates weight by increasing energy expenditure and reducing appetite. WuXi NextCODE's advanced artificial intelligence (AI) laboratory then applied its proprietary DeepCODE algorithm to score the variants for their predictive impact on obesity. Testing people living with obesity for the highest impact variants in these genes may enable the identification of those who may be candidates for treatment with therapies developed to target the MC4R pathway, as well as to a broader understanding of the mechanisms through which this pathway contributes to obesity.