~ New RT-114 obesity program combines ProGen’s FC Fusion protein conjugated GLP-1/GLP-2 dual agonist, PG-102, with the RaniPill® capsule designed to provide a differentiated oral delivery mechanism with bioavailability comparable to subcutaneous injection ~
~ Rani and ProGen to share responsibilities for the development and commercialization of RT-114, including a 50/50 cost and revenue share arrangement ~
~ Rani to host conference call today at
“This collaboration with ProGen reinforces Rani’s clear commitment to improving the lives of people suffering from chronic conditions, such as obesity, by replacing painful injections with the convenience of a pill,” said
“This partnership brings together Rani’s oral biologics delivery expertise with ProGen’s two decades of experience in Fc-fusion proteins to enable development of a potentially unique oral therapy option for people with obesity,” said Dr.
Under the terms of the collaboration agreement, Rani and ProGen agree to share responsibilities for the development and commercialization of RT-114 worldwide, including a 50/50 cost and revenue share arrangement. Rani has exclusive rights to lead development and commercialization of RT-114 in
Rani has developed the RaniPill® capsule, which is a novel, proprietary and patented platform technology, intended to replace subcutaneous injection or intravenous infusion of biologics and drugs with oral dosing. Rani has tested 15 molecules in the RaniPill® platform. The RaniPill® platform has delivered antibodies, peptides and large proteins with high bioavailability. To date, Rani has completed three Phase 1 clinical studies with the RaniPill® capsule. Additionally, ProGen’s preclinical studies demonstrated that treatment with PG-102 resulted in greater glycemic control while inducing a similar degree of body weight loss versus semaglutide and tirzepatide.1
ProGen recently presented results from its Phase 1 single-ascending dose study of PG-102, a GLP-1/GLP-2 dual agonist, at the 2024
Conference Call
Rani will host a corresponding conference call and live webcast on
About
About ProGen
ProGen is a South Korean clinical-stage biotech company developing next generation long-acting biologics for the treatment of metabolic diseases (obesity, type 2 diabetes, etc.) and immune-mediated diseases (inflammatory diseases and cancer). ProGen harnesses its proprietary technology platform known as Neo Tri-ImmunoGlobulin (NTIG®) that enables multi-targeting and allows drugs to have longer in vivo persistence than conventional Fc-fusion proteins. ProGen is currently focusing on the development of its lead product PG-102, a GLP-1/GLP-2-NTIG® fusion protein for the treatment of obesity and type 2 diabetes. PG-102 has shown improvement of body composition and glycemic control compared to tirzepatide in mouse models of obesity with and without type 2 diabetes.2 PG-102 is currently being investigated in a Phase 1b multiple ascending dose trial in
Forward-Looking Statements
Statements contained in this press release regarding matters that are not historical facts are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include statements regarding, among other things, the potential for RT-114 to be an oral treatment for obesity, the potential for RT-114 to be dosed weekly or less frequently, the potential for RT-114 to have a unique and differentiated product profile, success of the collaboration with ProGen and related activities, and the potential for Rani to make oral biologics a reality for millions of patients living with chronic conditions. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Words such as “believe,” “design,” “intend,” “look forward,” “could,” “plan,” “goal,” “potential,” “will,” “would” and similar expressions are intended to identify forward-looking statements. These forward-looking statements are based upon Rani’s current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, risks and uncertainties associated with Rani’s business in general and the other risks described in Rani’s filings with the
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1 PG-102, Next Generation GLP-1/GLP-2 Dual Agonist for the Treatment of Metabolic Diseases. Presentation at 2024 BIO Korea
2 Fat-specific weight loss in diet-induced obesity mouse model when treated with bispecific GLP-1R/GLP-2R agonist vs. dual GLP1R/GIPR agonist. Presentation at 59th EASD Annual Meeting
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