Item 2.02 Results of Operations and Financial Condition.

On January 12, 2021, Provention Bio, Inc. (the "Company") filed a preliminary prospectus supplement in connection with a proposed public offering of the Company's common stock, which contained information regarding the Company's preliminary, unaudited estimate of its cash, cash equivalents and marketable securities as of December 31, 2020 of $121.8 million (the "Preliminary Financial Information").

The Preliminary Financial Information is preliminary and subject to completion. The Preliminary Financial Information is the responsibility of management and has been prepared in good faith on a consistent basis with prior periods. However, the Company has not completed its financial closing procedures for the three months and year ended December 31, 2020, and its actual results could be materially different from the Preliminary Financial Information. In addition, EisnerAmper LLP, the Company's independent registered public accounting firm, has not audited, reviewed, compiled, or performed any procedures with respect to the Preliminary Financial Information and does not express an opinion or any other form of assurance with respect to the Preliminary Financial Information. During the course of the preparation of the Company's financial statements and related notes as of and for the year ended December 31, 2020, the Company may identify items that would require it to make material adjustments to the Preliminary Financial Information. As a result, undue reliance should not be placed on the Preliminary Financial Information, and it should not be viewed as a substitute for full financial statements prepared in accordance with United States generally accepted accounting principles.

The information furnished under this Item 2.02 shall not be considered "filed" under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), nor shall it be incorporated by reference into any future filing under the Securities Act of 1933, as amended, or under the Exchange Act, unless the Company expressly sets forth in such future filing that such information is to be considered "filed" or incorporated by reference therein.

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