Item 8.01Other Events.

On January 21, 2022, Orchard Therapeutics plc issued a press release titled "Orchard Therapeutics Announces Publication in The Lancet of Long-term Results on Libmeldy® for the Treatment of Children with Early-onset MLD." A copy of the press release is attached as Exhibit 99.1 to this current report on Form 8-K and is incorporated herein by reference.

Item 9.01 Financial Statements and Exhibits.



(d) Exhibits.



Exhibit
Number                                     Description
99.1        Press release dated January 21, 2022
104       Cover page interactive data file (embedded within the Inline XBRL document)

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