AstraZeneca and Merck's LYNPARZA Reduced the Risk of Disease Progression or Death by 70% Versus Placebo in BRCAm Advanced Ovarian Cancer Following Response to Platinum-Based Chemotherapy.

AstraZeneca and Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the companies have received marketing authorization from China's National Medical Products Administration (NMPA) for LYNPARZA as a first-line maintenance treatment of adult patients with newly diagnosed advanced germline or somatic BRCA-mutated (gBRCAm or sBRCAm) epithelial ovarian, fallopian tube or primary peritoneal cancer who are in complete or partial response to first-line platinum-based chemotherapy.

The approval in China is based on the results from the pivotal Phase 3 SOLO-1 trial, which were published in the New England Journal of Medicine. Results showed that LYNPARZA significantly reduced the risk of disease progression or death by 70% versus placebo in women with BRCAm advanced ovarian cancer following response to platinum-based chemotherapy (HR 0.30 [95% CI, 0.23-0.41], p

(C) 2019 Electronic News Publishing, source ENP Newswire