Horizon Pharma Public Limited Company announced that on January 18, 2018, Dave A. Happel notified the company that he intended to resign from the company, effective February 1, 2018, as Executive Vice President, Commercial Development and Strategy. Mr. Happel has been named Chief Executive Officer of Chrono Therapeutics. The company does not expect to replace the position and Mr. Happel's duties will be assumed by other members of executive team.