Item 3.03 Material Modification to Rights of Security Holders.

To the extent required by Item 3.03 of Form 8-K, the information regarding the Reverse Stock Split (as defined below) contained in Item 5.03 of this Current Report on Form 8-K is incorporated by reference herein.

Item 5.03 Amendments to Articles of Incorporation or Bylaws; Change in Fiscal


          Year.



On January 13, 2023, First Wave BioPharma, Inc. (the "Company") held a special meeting of stockholders (the "Special Meeting"). At the Special Meeting, the Company's stockholders approved the Reverse Stock Split Proposal, as defined below, thereby granting the Company's Board of Directors (the "Board") the discretion to effect a reverse stock split of the Company's issued and outstanding common stock, par value $0.0001 (the "Common Stock"), through an amendment (the "Amendment") to its Amended and Restated Certificate of Incorporation, as amended to date (the "Charter"), at a ratio of not less than 1-for-3 and not more than 1-for-40, with such ratio to be determined by the Board.

On January 13, 2023, the Company filed the Amendment to its Charter with the Secretary of State of the State of Delaware to effect a reverse stock split of its Common Stock at a ratio of 1-to-7 (the "Reverse Stock Split"). The Reverse Stock Split will become effective in accordance with the terms of the Amendment at 12:01 AM Eastern Time on January 18, 2023 (the "Effective Time"). First Wave's Common Stock will continue to be traded on The Nasdaq Capital Market under the symbol FWBI and will begin trading on a split-adjusted basis when the market opens on Wednesday, January 18, 2023, under a new CUSIP number, 33749P309.

At the Effective Time, every 7 shares of the Company's issued and outstanding Common Stock will be converted automatically into one issued and outstanding share of Common Stock, with no corresponding reduction in the number of authorized shares of Common Stock, and without any change in the par value per share. Stockholders holding shares through a brokerage account will have their shares automatically adjusted to reflect the 1-for-7 Reverse Stock Split. It is not necessary for stockholders holding shares of the Common Stock in certificated form to exchange their existing stock certificates for new stock certificates of the Company in connection with the Reverse Stock Split, although stockholders may do so if they wish.

The Reverse Stock Split will affect all stockholders uniformly and will not alter any stockholder's percentage interest in the Company's equity, except to the extent that the Reverse Stock Split would result in a stockholder owning a fractional share. No fractional shares will be issued in connection with the Reverse Stock Split. Stockholders who would otherwise be entitled to receive a fractional share will instead receive a cash payment (without interest) equal to such fraction multiplied by the average of the closing sales prices of Common Stock on The Nasdaq Capital Market for the five consecutive trading days immediately preceding the effective date of the Reverse Stock Split (with such average closing sales prices being adjusted to give effect to the Reverse Stock Split). The Reverse Stock Split will reduce the number of shares of Common Stock outstanding from approximately 6,965,024 shares to approximately 995,003 shares. Proportional adjustments will be made to the number of shares of Common Stock issuable upon exercise or conversion of the Company's equity awards, convertible preferred stock and warrants, as well as the applicable exercise price. Stockholders with shares in brokerage accounts should direct any questions concerning the Reverse Stock Split to their broker; all other stockholders may direct questions to the Company's transfer agent, Colonial Stock Transfer, at 801-355-5740.

The foregoing description of the Amendment does not purport to be complete and is qualified in its entirety by reference to the full text of the Amendment, which is filed as Exhibit 3.1 to this Current Report on Form 8-K and incorporated by reference herein.

Item 5.07 Submission of Matters to a Vote of Security Holders.

On January 13, 2023, the Company held the Special Meeting. The matters voted on at the Special Meeting were: (1) the approval of the issuance of more than 20% of our Common Stock pursuant to the private placement and warrant amendment for purposes of Nasdaq Listing Rule 5635(d) (the "Private Placement Proposal"), (2) the adoption and approval of the Amendment to the Company's Charter to effect a reverse stock split of the Company's issued and outstanding shares of Common Stock, at a specific ratio, ranging from one-for-three (1:3) to one-for-forty (1:40), at any time prior to the one-year anniversary date of the Special Meeting with the exact ratio to be determined by the Board without further approval or authorization of the Company's stockholders (the "Reverse Stock Split Proposal") and (3) the approval of the adjournment of the Special Meeting to the extent there are insufficient votes at the Special Meeting to approve any one or more of the foregoing proposals (the "Adjournment Proposal").

At the Special Meeting, all of the matters voted on were approved, based upon an aggregate of 5,804,671 shares of Common Stock and 5,804.671 shares of the Company's Series F Preferred Stock outstanding as of December 8, 2022, which was the record date for the Special Meeting. The final voting results were as follows:

1. The Private Placement Proposal.

The votes were cast for this matter as follows:





Votes For   Votes Against   Abstentions   Broker Non-Votes
 528,701       496,698        52,341         1,262,765



2. The Reverse Stock Split Proposal.

The votes were cast for this matter as follows:





  Votes For     Votes Against   Abstentions
1,625,633,905    574,231,665    142,979,935




3. The Adjournment Proposal.


The votes were cast for this matter as follows:





  Votes For     Votes Against   Abstentions
1,584,130,826    592,147,779    166,566,900

Item 7.01 Regulation FD Disclosure.

On January 13, 2023, the Company issued a press release announcing the results of the Special Meeting, a copy of which is furnished as Exhibit 99.1 to this Current Report on Form 8-K.

Item 9.01 Financial Statements and Exhibits.







  (d) Exhibits.





Exhibit No. Description

  3.1         Certificate of Amendment to the Amended and Restated Certificate of
            Incorporation, as amended, of First Wave BioPharma, Inc., dated January
            13, 2023.
  99.1        Press Release, dated January 13, 2023.
104         Cover Page Interactive Data File (embedded within the Inline XBRL
            document).

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