Diamyd Medical AB (publ) announced that in a fifth interim report from the open label investigator initiated clinical pilot trial DIAGNODE-1, where the diabetes vaccine Diamyd® is administered directly into the lymph node, results are presented for the first four patients that have been followed for the entire study period, 30 months. No serious side effects have been reported and positive effects are seen on the disease progression. On average, the patients' own ability to produce insulin (measured by C-peptide, AUC) has decreased by 32%, while at the same time, patients have on average lower (-15%) long-term blood sugar (HbA1c) and use less insulin (-22%) than at the start of the trial. In summary, these data indicate that the disease progression continues to be positive at 30 months for these first four patients. DIAGNODE-1 is an open label pilot trial, comprising a total of twelve patients between the ages of 12 and 30 with type 1 diabetes, where the diabetes vaccine Diamyd® is administered three times, one month apart, in a low (4µg) dose directly into the lymph node. The treatment is combined with oral vitamin D. Twelve patients have been followed for 6 months and out of these six patients have been followed for 15 months from inclusion and four have been followed for the entire study period, 30 months. DIAGNODE-2 is a follow-up on DIAGNODE-1, where preliminary results show a positive clinical progression and desired immunological response as the diabetes vaccine Diamyd® is given directly into the lymph node. DIAGNODE-2 is a double-blind randomized trial encompassing approximately 80 patients from Sweden, the Czech Republic and Spain, aged 12­24 years that have recently been diagnosed with type 1 diabetes. The patients will be followed for 15 months with the aim to evaluate the remaining insulin producing capacity.