BERKELEY -
Breast cancer is subdivided into 3 categories based on its appearance under the microscope: Grade 1 (well differentiated), Grade II (moderately differentiated) and Grade III (poorly differentiated). The Bria-IMT cell line was derived from a Grade II tumor biopsy. Upon reanalysis of our clinical data, we learned of correlative patterns of tumor response in Grade I/II breast cancer patient populations. In our view, this seems logical because Bria-IMT is derived from a Grade II (moderately differentiated) breast cancer tumor. Importantly, approximately 40% of recurrent breast cancers are Grade I/II.
Monotherapy: The clinical benefit rate in our monotherapy studies for Grade I/II patients with immune responses was 5/7 (71%) despite the fact that these patients were very heavily pre-treated with a median of 7 prior regimens (such as chemotherapy).
Combination study of Bria-IMT with KEYTRUDA: All 3 patients with Grade I/II tumors had clinical benefit (100%). All of these patients had been very heavily pre-treated with 14-15 prior regimens.
Further analysis of our patients with Grade I/II tumors shows that patients with greatest tumor reductions within the Grade I/II subset also had double HLA matches with Bria-IMT in both monotherapy and combination study groups. Based on our new findings, we believe we are able to identify a sizeable patient population who will derive significant clinical benefit from treatment with Bria-IMT, adding further biomarker capability incremental to our HLA-matching hypothesis.
'We believe that we have identified an important and sizeable subgroup of patients who will benefit from our novel immunotherapy treatments. We plan to further validate these findings in subsequent patients, strengthening yet another responder biomarker technique,' stated
About BriaCell
BriaCell is an immuno-oncology focused biotechnology company developing targeted and safe approaches for the management of cancer.
BriaCell is conducting a Phase I/IIa clinical trial of Bria-IMT, BriaCell's lead candidate, in a Combination Study with immune checkpoint inhibitors such as the
BriaCell currently has a non-exclusive clinical trial collaboration with
BriaCell is also developing Bria-OTS, an off-the-shelf personalized immunotherapy, for advanced breast cancer. Bria-OTS immunotherapy treatments are personalized to match the patient without the need for personalized manufacturing. Bria-OTS, which is expected to cover over 99 percent of the patient population, is designed to produce a potent and selective immune response against the cancer of each patient while eliminating the time, expense and complex manufacturing logistics associated with other personalized immunotherapies.
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Contact:
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Email: farrah@BriaCell.com
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