On January 5, 2022, Mr. Joseph Vazzano notified Avenue Therapeutics, Inc. that he was resigning from his role as the Company's Chief Financial Officer, effective January 14, 2022, to pursue other opportunities. On January 7, 2022 the Company's Board of Directors appointed Dr. Lucy Lu, M.D., the Company's President and Chief Executive Officer, as the Company's interim Chief Financial Offier and Principal Financial Officer.