Alligator Bioscience : Announces Publication Highlighting Potential of Next Generation CD40 Agonists in Peer Reviewed Medical Journal "Expert Opinion on Biological Therapy"
May 20, 2024 at 12:08 pm EDT
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Published: 2024-05-20 15:00:00 CEST
Alligator Bioscience AB
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Alligator Bioscience Announces Publication Highlighting Potential of Next-Generation CD40 Agonists in Peer-Reviewed Medical Journal "Expert Opinion on Biological Therapy"
Next-generation CD40 agonists have opportunity to address key biological and medical needs in immuno-oncology
Bispecific CD40-targeting antibodies, as those developed using Alligators Neo-X-Prime ® technology, maximize the ability of CD40 to remodel tumor microenvironment and boost anti-tumor T cell response
CD40 targeting bispecific antibodies, such as ATOR-4066 developed by Alligator, can take CD40 agonists to the next level in terms of efficacy and safety
Lund, Sweden - Alligator Bioscience (Nasdaq Stockholm: ATORX) today announces the publication of a scientific article detailing the potential of next-generation CD40-targeting therapies in immuno-oncology in the peer-reviewed medical journal "Expert Opinion on Biological Therapy".
The article, entitled "Next generation CD40 agonists for cancer immunotherapy" highlights how:
Bispecific CD40-targeting antibodies, as those developed using Alligators Neo-X-Prime ® platform, that maximize the ability of CD40 to both remodel the tumor microenvironment and boost the anti-tumor T cell response have the potential to meet key needs in immuno-oncology
Enhancing efficacy is the most important driver for developing new CD40-targeting therapies while ensuring safety is also critical to allow effective dosing in combination with other treatment modalities
Enhanced understanding of the role of different CD40-expressing immune cells in the tumor microenvironment may facilitate more efficient clinical development of these compounds
"There is a need in oncology for new therapies that can enhance response rates and broaden the number of cancer indications where immunotherapies provide clinical benefit," said Peter Ellmark, CSO of Alligator Bioscience and one of the authors of the article."CD40-targeting therapies, such as Alligators ATOR-4066 program developed using our Neo-X-Prime® platform, provide an opportunity to meet this need by promoting priming of tumor-specific T cells and reverting the immunosuppressive nature of the tumor microenvironment. The coming wave of next-generation CD40 agonists uses new approaches and formats which go beyond monospecific antibodies to improve efficacy and safety and provide great opportunities to benefit cancer patients."
The full article is available online via this link.
Alligator Bioscience AB is a clinical-stage biotechnology company developing tumor-directed immuno-oncology antibody drugs. Alligator's portfolio includes several promising drug candidates, with the CD40 agonist mitazalimab as its key asset. Furthermore, Alligator is co-developing ALG.APV-527 with Aptevo Therapeutics Inc., several undisclosed molecules based on its proprietary technology platform, Neo-X-Prime®, and novel drug candidates based on the RUBY® bispecific platform with Orion Corporation. Out-licensed programs include AC101/HLX22, in Phase 2 development, by Shanghai Henlius Biotech Inc. and an undisclosed target to Biotheus Inc.
Alligator Bioscience's shares are listed on Nasdaq Stockholm (ATORX) and is headquartered in Lund, Sweden.
For more information, please visit alligatorbioscience.com.
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Alligator Bioscience Announces Publication Highlighting Potential of Next-Generation CD40 Agonists in Peer-Reviewed Medical Journal Expert Opinion on Biological Therapy.pdf
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Alligator Bioscience AB is a Sweden-based biotechnology Company that develops antibody-based drugs for cancer treatment. The Company specializes in the development of tumor-targeted immunotherapies, in particular agonist mono- and bispecific antibodies, and is active in the early stages of drug development, from concept to phase II clinical trials. Alligatorâs pipeline includes the two key assets mitazalimab, a CD40 agonist, and ATOR-1017, a 4-1BB agonist. Furthermore, Alligator is co-developing ALG.APV-527 with Aptevo Therapeutics Inc., several undisclosed molecules based on its technology platform, Neo-X-Prime, with MacroGenics Inc. and drug candidates based on the RUBY bispecific platform with Orion Corporation. Its licensed programs include AC101, in phase II development, by Shanghai Henlius Biotech Inc. and an undisclosed target to Biotheus Inc. The Company operates domestically.
Alligator Bioscience : Announces Publication Highlighting Potential of Next Generation CD40 Agonists in Peer Reviewed Medical Journal "Expert Opinion on Biological Therapy"