Poolbeg Pharma announced promising in vivo results for POLB 001 in addressing cancer immunotherapy-induced CRS. Positive study results POLB 001 demonstrated efficacy in reducing cancer immunotherapy-induced C RS in an in vivo animal model with CRS symptoms significantly improved following administration of POLB 001. Red reductions were seen in all serum proinflammatory cytokines tested.

The results, together with the data from the recent LPS human challenge tria l, further support the Company's strategic expansion of the Phase II ready POLB 001 to treat and prevent cancer immunotherapy-induced CS. In the U.S., the American Cancer Society estimates that there will be 24.6 million cases of cancer by 2030. Cancer immunotherapies, such as bispecific antibodies and CAR T cell therapy, are rapidly moving into earlier lines of treatment in many tumour types, with these markets anticipated to grow to USD 100 billion+ (35% CAGR) by 2030.