EMERYVILLE - Kyverna Therapeutics ('Kyverna'), a clinical-stage cell therapy company with the mission of engineering a new class of therapies for serious autoimmune diseases, today announced a non-exclusive, multi-year license and supply agreement with
The LentiVector platform is the first commercially approved lentiviral-based gene delivery system. The platform enables the successful development of breakthrough gene and cell-based medicines.
Kyverna's anti-CD19 chimeric antigen receptor (CAR) T-cell therapies, KYV-101 and KYV-201, specifically target CD19, a protein expressed on the surface of B cells which are involved in various types of autoimmune diseases, including lupus nephritis. These novel therapies have the potential to offer new hope to patients who have exhausted current treatment options. Kyverna's KYV-101 CAR T-cell product is currently being tested in a Phase 1 clinical trial in lupus nephritis in the
'We are committed to quality and innovation. As a world-leading CDMO with expertise across all key viral vector types, we are committed to enabling our biopharma customers to discover and deliver transformative therapies', said Dr.
'We are delighted to be working with
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One of the original pioneers in cell and gene therapy,
About KYV-101
KYV-101 is an autologous version of a novel, fully human clinical-stage anti-CD19 chimeric antigen receptor (CAR) T-cell construct with properties well suited for use in B cell-driven autoimmune diseases such as lupus nephritis and other B-cell driven autoimmune diseases. In a 20-patient Phase 1/2 study in oncology, expected anti-lymphoma activity was associated with a significant reduction of cytokines released that translated into a strong reduction of cytokine-driven side effects such as the rate of immune effector cell-associated neurotoxicity syndrome (ICANS)1. The fully human anti-CD19 CAR also translated into reduced immunogenicity that favorably impacted cell persistence at one month. Kyverna recognized that these properties singled out KYV-101 as a product ideally poised for use in autoimmune disease patients, and the company obtained exclusive, worldwide licenses from the
About Kyverna Therapeutics
Kyverna Therapeutics is a clinical-stage cell therapy company with the mission of engineering a new class of therapies for autoimmune and inflammatory diseases. The Kyverna therapeutic platform combines advanced T-cell engineering and synthetic biology technologies to suppress and eliminate the autoreactive immune cells at the origin of autoimmune and inflammatory diseases. Kyverna's pipeline includes next-generation chimeric antigen receptor (CAR) T-cell therapies in both autologous and allogeneic formats with properties well suited for use in B cell-driven autoimmune diseases. By offering more than one mechanism for taming autoimmunity, Kyverna is positioned to act on its mission of transforming how autoimmune diseases are treated.
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Email: christian.pflaumer@ruderfinn.com
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