Item 5.02 Departure of Directors or Certain Officers; Election of Directors;


          Appointment of Certain Officers; Compensatory Arrangement of Certain
          Officers.


On February 28, 2023, the Board of Directors of Graybug Vision, Inc. ("Graybug")
determined it to be in Graybug's best interests to terminate Parisa Zamiri's
employment in advance of the anticipated closing date of the Merger (as defined
below), and to provide her the payments to which she is entitled under Graybug's
Change in Control Severance Policy (the "CIC Severance Policy"). In connection
with Dr. Zamiri ceasing to serve as Graybug's Chief Medical Officer, Graybug
entered into a separation agreement with Dr. Zamiri, dated February 28, 2023,
pursuant to which, following Dr. Zamiri's execution of a general release of
claims in favor of Graybug, she will receive (i) $829,084, less applicable state
and federal payroll deductions, equal to 15 months of her current base salary
and 1.25 times her bonus target rate of 40% of her annual base salary,
(ii) payment of the premiums for her continued health insurance under COBRA for
up to 15 months and (iii) 100% acceleration of outstanding stock awards, subject
to the settlement restrictions set forth in the Merger Agreement (as defined
below). The foregoing payments and benefits are consistent with those that would
have been payable under the CIC Severance Policy had her employment terminated
on the actual closing date of the Merger. On February 28, 2023, Dr. Zamiri also
entered into a consulting agreement with Graybug, pursuant to which she will be
paid $350 per hour for any work requested by Graybug up to a maximum of 8 hours
per week, unless otherwise mutually agreed by Graybug and Dr. Zamiri. The
consulting agreement terminates upon the earlier of 15 days prior notice by
Graybug or May 21, 2023.


Item 8.01 Other Events.


As previously announced, on November 21, 2022, Graybug, Camaro Merger Sub, Inc.
("Merger Sub") and CalciMedica, Inc. entered into an Agreement and Plan of
Merger, as amended on February 10, 2023 (the "Merger Agreement"), pursuant to
which, among other matters, and subject to the satisfaction or waiver of the
conditions set forth in the Merger Agreement, Merger Sub will merge with and
into CalciMedica with CalciMedica continuing as a wholly owned subsidiary of
Graybug and the surviving corporation of the merger (the "Merger").

In connection with the Merger, Graybug filed with the Securities and Exchange
Commission (the "SEC") a definitive proxy statement, dated February 9, 2023 (the
"Proxy Statement"), which Graybug commenced mailing to its stockholders on or
about February 13, 2023. Set forth below are supplemental disclosures relating
to the Merger.

                            SUPPLEMENTAL DISCLOSURE

Graybug is hereby supplementing the Proxy Statement with the information set
forth below (the "Supplemental Disclosure") solely to eliminate the burden and
expense of the Stockholder Litigation and Demand Letters (described in the
"Legal Proceedings" section, below), and to avoid any possible disruption to the
Merger. The Supplemental Disclosure contained below should be read in
conjunction with the Proxy Statement, which is available on the Internet site
maintained by the SEC at http://www.sec.gov. To the extent that information in
the Supplemental Disclosure differs from or updates information contained in the
Proxy Statement, you should rely on the information in the Supplemental
Disclosure, which supersedes or supplements the Proxy Statement. References to
sections below are references to the corresponding sections of the Proxy
Statement; page references below are references to pages in the Proxy Statement
prior to any additions or deletions resulting from the Supplemental Disclosure;
and any capitalized terms used but not defined herein shall have the meanings
ascribed to such terms in the Proxy Statement.

Graybug is also providing additional supplemental disclosures reflecting the occurrence of certain events following the filing of the Proxy Statement.

Graybug does not believe that the Supplemental Disclosure is required or necessary under applicable laws, and nothing in the Supplemental Disclosure should be deemed to be an admission of the legal necessity or materiality of any Supplemental Disclosure.

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The Supplemental Disclosure is dated March 3, 2023, and you should not assume
that the information contained in the Supplemental Disclosure is accurate as of
any other date, except as otherwise specified in the Supplemental Disclosure.

The Supplemental Disclosures are as follows:

Background of the Merger

The following additional information supplements the information disclosed under the heading "The Merger - Background of the Merger," which begins on page 96:



The 15 preliminary proposals contained a range of economic terms. Ten proposed
reverse mergers, and of those, the value ascribed to Graybug was between
$25 million and $50 million, with associated pro forma ownership of 33% to 14%,
respectively, of common stock of the combined company. Two of the proposals were
for divestitures of Graybug assets and ranged from a $2 million upfront payment
with no royalties to no upfront payment and royalties of between 5% and 7% on
net sales from the acquired asset, depending on the use of certain claims. Two
proposed merger transactions, each to be paid in the acquirer's equity with pro
forma ownership of 9% to 45%, respectively, of common stock of the combined
company.

Certain Unaudited Financial Projections and Liquidation Analysis

Under the heading "The Merger - Certain Unaudited Financial Projections and Liquidation Analysis" the final table of this section, which begins on page 122, is hereby amended and restated as follows (with new text in bold):



                              FY          FY          FY          FY          FY          FY          FY         FY         FY         FY         FY         FY         FY         FY         FY         FY
                             2023        2024        2025        2026        2027        2028        2029       2030       2031       2032       2033       2034       2035       2036       2037       2038
Total Revenue1                  -           -           -           -        $   1       $  23       $  90      $ 192      $ 338      $ 478      $ 545      $ 576      $ 599      $ 622      $ 645      $ 668
Gross Profit                    -           -           -           -        $  (0 )     $  17       $  73      $ 169      $ 315      $ 459      $ 528

$ 559 $ 581 $ 603 $ 625 $ 648 Total Operating Expenses 19 29 45 52

$  63       $  58       $  60      $  63      $  67      $  70      $  73      $  77      $  81      $  85      $  89      $  93
EBITDA2                      ($ 19 )     ($ 29 )     ($ 45 )     ($ 52 )     ($ 64 )     ($ 41 )     $  12      $ 105      $ 249      $ 389      $ 455      $ 482      $ 501      $ 518      $ 536      $ 555
Cash Taxes Payable3             -           -           -           -           -           -        $   1      $   5      $  12      $  89      $ 114

$ 120 $ 125 $ 130 $ 134 $ 139 Unlevered Free Cash Flow4 ($ 19 ) ($ 29 ) ($ 45 ) ($ 52 )


 ($ 64 )     ($ 41 )     $  12      $ 100      $ 237      $ 300      $ 341      $ 361      $ 375      $ 389      $ 402      $ 416

(1) Reflects assumptions regarding probability of success (including regulatory

approvals) and of commercialization.

(2) EBITDA means earnings before interest, taxes, depreciation and amortization.

(3) Assumes tax rate of 25% and NOL beginning balance of $64.5 million as of

December 31, 2021 plus $11.0 million operating loss.

(4) Represents EBITDA less cash taxes payable.

Opinion of Graybug's Financial Advisor.



Under the heading "The Merger - Opinion of Graybug's Financial Advisor" and the
subheading "Financial Review of Graybug" the first and only paragraph of this
subsection, which begins on page 109, is hereby amended and restated as follows
(with new text in bold):

Piper Sandler reviewed, among other things, the current implied equity and
enterprise valuations, capitalization and cash balances, and projected closing
capitalization and cash balances of Graybug. The analysis indicated, among other
things, that Graybug had diluted shares outstanding as of September 30, 2022 of
approximately 25.1 million calculated using the treasury stock method ("TSM")
and based on the closing stock price of Graybug on November 18, 2022, cash, cash
equivalents and short-term investments on hand (referred to herein as net cash)
as of September 30, 2022 of approximately $43.6 million, a current implied
enterprise value of approximately $(19.8) million, and estimated net cash at the
consummation of the merger of approximately $26.5 million (the "Graybug Closing
Cash"). References below to an assumed Graybug intrinsic value are references to
an assumed intrinsic value of $1.06 per share, based on the quotient of the
Graybug Closing Cash and such number of diluted shares.

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Under the heading "The Merger - Opinion of Graybug's Financial Advisor" and the
subheading "Financial Analyses of CalciMedica-Selected Public Companies
Analysis" the fourth and fifth paragraphs of this subsection, which begin on
page 109, are hereby amended and restated as follows (with new text in bold):

For the selected biotech public companies analysis, Piper Sandler derived a
range of implied enterprise values for CalciMedica based on the implied
enterprise value range for the selected public companies referred to above and
then adjusted for net cash of approximately $11.5 million, to calculate an
implied range of CalciMedica equity values. Piper Sandler then derived an
implied number of shares of Graybug common stock to be issued in the merger,
based on a Graybug intrinsic value of $1.06 per share. Piper Sandler also
calculated an implied pro forma equity value for the combined company by
adjusting the implied enterprise value for CalciMedica for pro forma net cash at
the consummation of the merger of approximately $11.5 million for CalciMedica
and the Graybug Closing Cash for Graybug. This analysis did not account for any
assumed additional cash needs of CalciMedica to fund its business plan.

Based on the minimum, 25th percentile, median, mean, 75th percentile, and
maximum implied equity values for CalciMedica derived above, Piper Sandler then
calculated the corresponding (a) implied ownership percentages range for Graybug
stockholders in the combined company and (b) implied exchange ratios range for
the merger, calculated by dividing the shares contemplated to be issued to
CalciMedica stockholders in the merger (of approximately 44 - 722 million based
on the range of implied equity values of CalciMedica from this selected public
companies analysis) by CalciMedica's diluted shares outstanding as of
September 30, 2022 of approximately 147 - 175 million calculated using TSM and
in the manner described above:

Under the heading "The Merger - Opinion of Graybug's Financial Advisor" and the
subheading "Financial Analyses of CalciMedica-Selected IPOs Analysis" the fourth
and fifth paragraphs of this subsection, which begin on page 111, are hereby
amended and restated as follows (with new text in bold):

For the selected biotech IPO companies analysis, Piper Sandler derived a range
of implied enterprise values for CalciMedica based on the implied adjusted
pre-money enterprise value range for the selected IPO companies referred to
above and then adjusted for net cash of approximately $11.5 million, to
calculate an implied range of CalciMedica equity values. Piper Sandler then
derived an implied number of shares of Graybug common stock to be issued in the
merger, based on a Graybug intrinsic value of $1.06 per share. Piper Sandler
also calculated an implied pro forma equity value for the combined company by
adjusting the implied enterprise value for CalciMedica for pro forma net cash at
the consummation of the merger of approximately $11.5 million for CalciMedica
and the Graybug Closing Cash for Graybug. This analysis did not account for
assumed additional cash needs of CalciMedica to fund its business plan.

Based on the minimum, 25th percentile, median, mean, 75th percentile, and
maximum implied equity values for CalciMedica derived above, Piper Sandler then
calculated the corresponding (a) implied ownership percentages range for Graybug
stockholders in the combined company and (b) implied exchange ratios range for
the merger, calculated by dividing the shares contemplated to be issued to
CalciMedica stockholders in the merger (of approximately 124 - 239 million based
on the range of implied equity values of CalciMedica from this selected IPOs
analysis) by CalciMedica's diluted shares outstanding as of September 30, 2022
of approximately 159 - 168 million calculated using TSM and in the manner
described above:

Under the heading "The Merger - Opinion of Graybug's Financial Advisor" and the
subheading "Financial Analyses of CalciMedica-Discounted Cash Flows Analysis"
the second paragraph of this subsection, which begins on page 115, is hereby
amended and restated as follows (with new text in bold):

Based on the minimum, 25th percentile, median, mean, 75th percentile, and
maximum implied equity values for CalciMedica derived above, Piper Sandler then
calculated the corresponding (a) implied ownership percentages range for Graybug
stockholders in the combined company and (b) implied exchange ratios range for
the merger, calculated by dividing the shares contemplated to be issued to
CalciMedica stockholders in the merger (of approximately 129 - 505 million based
on the range of implied equity values of CalciMedica from this discounted cash
flow analysis) by CalciMedica's diluted shares outstanding as of September 30,
2022 of approximately 160 - 173 million calculated using TSM and in the manner
described above:

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Under the heading "The Merger - Opinion of Graybug's Financial Advisor" and the
subheading "Financial Analyses of CalciMedica-Subsequent Developments" the
second paragraph of this subsection, which begins on page 118, is hereby amended
and restated as follows (with new text in bold):

Subsequent to the November 21, 2022 Graybug Board meeting, Piper Sandler was
informed that the diluted share information for CalciMedica provided to it by
CalciMedica's management, which was used in conducting the foregoing financial
analyses, included an incorrect assumption and Piper Sandler was provided with
the corrected diluted share information. Such corrected diluted share
information resulted in ranges of diluted shares outstanding of 146 -
174 million, 158 - 167 million, and 159 - 172 million for the selected public
companies analysis, the selected IPOs analysis and the discounted cash flow
analysis, respectively (none of which impacted the range of shares of Graybug
common stock contemplated to be issued to CalciMedica stockholders in the
merger). This discovery did not result in any change to Piper Sandler's fairness
opinion or its conclusion. Piper Sandler did, however, provide the Graybug Board
with the revised exchange ratio analyses reflecting the corrected diluted share
information, which indicated the implied exchange ratios set forth below. These
revisions did not impact the implied ownership percentages for Graybug
stockholders in the combined company or the implied per share values of Graybug
common stock.

Under the heading "The Merger - Opinion of Graybug's Financial Advisor" and the
subheading "Information about Piper Sandler" the second paragraph of this
subsection, which begins on page 118, is hereby amended and restated as follows
(with new text in bold):

Piper Sandler acted as a financial advisor to Graybug in connection with the
merger and will receive a fee of $3,000,000 from Graybug for providing its
services, which is contingent upon the consummation of the merger, except for
(i) $100,000 of such fee which has been earned by Piper Sandler upon execution
of its engagement letter with Graybug (the "retainer fee"), and (ii) $750,000 of
such fee which has been earned by Piper Sandler for rendering its fairness
opinion (the "opinion fee"), each of which are creditable against the total fee.
The retainer fee and opinion fee were not contingent upon the consummation of
the merger or the conclusions reached in Piper Sandler's opinion. Graybug has
also agreed to indemnify Piper Sandler against certain liabilities and reimburse
Piper Sandler for certain expenses in connection with its services. Piper
Sandler has, in the past, provided financial advisory and financing services to
Graybug, as well as to certain stockholders of Graybug, including affiliates of
Deerfield Management Company, L.P. (along with its affiliates, "Deerfield") and
affiliates of OrbiMed Advisors LLC (along with its affiliates, "OrbiMed"), and
has received fees for the rendering of such services. In particular, since
January 1, 2020 Piper Sandler has (i) acted as Graybug's joint book-running
manager in connection with Graybug's initial public offering in September 2020
for which Piper Sandler received a fee of approximately $2,200,000, (ii)
provided certain financial advisory services to Deerfield in connection with
(a) approximately 4 merger and acquisitions transactions and (b) approximately
20 capital markets transactions, for which Piper Sandler received aggregate fees
of approximately $52,000,000, and (iii) provided certain financial advisory
services to OrbiMed in connection with (a) approximately 7 merger and
acquisitions transactions and (b) approximately 50 capital markets transactions,
for which Piper Sandler received aggregate fees of approximately $105,000,000.
In addition, in the ordinary course of its business, Piper Sandler and its
affiliates may actively trade securities of Graybug for their own account or the
account of their customers and, accordingly, may at any time hold a long or
short position in such securities. Since January 1, 2020, Piper Sandler had not
received any revenue in respect of any financial advisory or financing services
provided to CalciMedica. Piper Sandler may also, in the future, provide
investment banking and financial advisory services to Graybug, CalciMedica or
entities that are affiliated with Graybug or CalciMedica, for which Piper
Sandler would expect to receive compensation.

Legal Proceedings



Under the heading "Graybug's Business - Legal Proceedings", which begins on page
186, that subsection is hereby amended and restated as follows (with new text in
bold):

Four lawsuits have been filed in federal courts against Graybug and its
directors: Bushansky v. Graybug Vision, Inc., et al., 3:22-cv-09131 (N.D.
Cal.), Connelly v. Graybug Vision, Inc., et al., 3:23-cv-00028 (N.D. Cal.),
Plumley v. Graybug Vision, Inc., et al., 1:23-cv-00169 (D. Del.), and Franchi v.
Graybug Vision, Inc., et al., No. 1:23-cv-1390 (S.D.N.Y.) (collectively, the
"Stockholder Litigation"). The complaints name Graybug and the Graybug Board as
defendants. The complaints assert claims under Section 14(a) and Section 20(a)
of the Exchange Act and Rule 14a-19

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promulgated thereunder, and generally allege that the proxy statement
misrepresents and/or omits certain purportedly material information relating to
the merger, including allegations relating to the financial projections and
analyses of our financial advisor. The complaints seek a variety of equitable
and injunctive relief including, among other things, an injunction enjoining the
consummation of the merger, rescission of the merger if it is consummated,
rescissory damages and costs and attorneys' fees. We have not yet responded to
the complaints filed in the Stockholder Litigation.

In addition, nine purported stockholders of Graybug sent demand letters
regarding the proxy statement (the "Demand Letters"). Based on the same core
allegations as the Stockholder Litigation, the Demand Letters request that we
disseminate corrective disclosures in an amendment or supplement to the proxy
statement.

We believe the Stockholder Litigation and the Demand Letters are without merit,
but there can be no assurance that we will ultimately prevail in the Stockholder
Litigation or all such lawsuits. Further, additional lawsuits may be filed and
demand letters may be sent before the Special Meeting and/or the consummation of
the merger.

For a description of other material legal proceedings Graybug is party to,
please refer to the section entitled "Item 3. Legal Proceedings" set forth in
Graybug's Annual Report on Form 10-K for the year ended December 31, 2021 as
filed with the SEC on March 11, 2022, as updated by the subsequent quarterly
reports on Form 10-Q.

Annex A

Exhibit 2.1 to Graybug's Current Report on Form 8-K filed with the SEC on February 16, 2023 is added to Annex A of the Proxy Statement immediately following page A-128 and is hereby incorporated by reference.

Important Additional Information



In connection with the Merger, Graybug has filed with the U.S. Securities and
Exchange Commission (the "SEC") a definitive proxy statement relating to the
proposed Merger. BEFORE MAKING ANY VOTING DECISION, INVESTORS AND SECURITY
HOLDERS ARE URGED TO READ THE DEFINITIVE PROXY STATEMENT, ANY AMENDMENTS OR
SUPPLEMENTS THERETO, AND ANY OTHER DOCUMENTS TO BE FILED WITH THE SEC IN
CONNECTION WITH THE MERGER OR INCORPORATED BY REFERENCE IN THE PROXY STATEMENT
AS THEY CONTAIN IMPORTANT INFORMATION ABOUT GRAYBUG, CALCIMEDICA AND THE
PROPOSED MERGER. Investors and security holders may obtain free copies of these
documents on the SEC's web site at www.sec.gov, on Graybug's website at
https://investors.graybug.vision/ or by contacting Graybug's Investor Relations
via email at IR@graybug.vision or by telephone at (650) 487-2409.

Participants in the Solicitation

Graybug and its directors and certain of its executive officers may be deemed
participants in the solicitation of proxies from the stockholders of Graybug in
connection with the proposed Merger and any other matters to be voted on at the
special meeting. Information regarding the names, affiliations and interests of
such directors and executive officers are included in the definitive proxy
statement.

Information regarding the persons who may, under SEC rules, be deemed
participants in the solicitation of proxies of Graybug's stockholders in
connection with the proposed Merger and any other matters to be voted upon at
the special meeting is be set forth in the definitive proxy statement for the
Merger.

These documents are available free of charge as described in the preceding paragraph.

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