An interim analysis of a Phase III trial of Calquence (acalabrutinib) plus chemoimmunotherapy has revealed positive progression-free survival outcomes for adults with untreated mantle cell lymphoma.
Based on the high-level data, using Calquence in the first-line setting "significantly delays disease progression and, for the first time, shows potential to extend survival. The improvement in progression-free survival together with the differentiated safety profile of Calquence are both important as we strive to transform outcomes earlier in the course of disease treatment,"
"These positive progression-free survival results from the ECHO Phase III trial could provide a new standard of care for patients with mantle cell lymphoma”
"These positive progression-free survival results from the ECHO Phase III trial could provide a new standard of care for patients with mantle cell lymphoma. Incorporating Calquence into the first-line mantle cell lymphoma setting would give many more patients the opportunity to benefit from the robust efficacy and strong safety profile we've seen with this medicine," shared Dr
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While a trend in the secondary endpoint of overall survival in patients with mantle cell lymphoma was noted with this treatment combination, the data was not mature at the time of this analysis to draw conclusions, the company concluded.
This new results from the interim analysis will be presented at an upcoming medical meeting,
Calquence is currently being investigated as a monotherapy and in combination for multiple B-cell blood cancers. This include chronic lymphocytic leukaemia and diffuse large B-cell lymphoma.
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