On January 11, 2021, Taysha Gene Therapies, Inc. (the Company) entered into a lease agreement (the Lease) with Pegasus Park, LLC, a Delaware limited liability company (the Landlord), pursuant to which the Company will lease approximately 15,000 square feet of office space at 3000 Pegasus Park Drive, Dallas, Texas 75247. The Lease commences on the date on which certain improvements to the Office Space have been made and the Office Space is tendered to the Company for possession, which the Company and the Landlord presently anticipate to be delivered on or about April 15, 2021, and will have a term of approximately ten years. The Company has an option to extend the term of the Lease for one additional period of five years. The Company's obligation for the payment of base rent for the Office Space will initially be approximately $32,500.00 per month and will increase annually, up to an estimated monthly base rent of $50,418.17 during the term of the Lease. The Company is obligated to pay operating costs and utilities applicable to the Office Space. The Company was required to provide a security deposit of $32,500.00 in connection with its entry into the Lease. The Company will be responsible for costs of constructing interior improvements within the Office Space that exceed a construction allowance provided by the Landlord not to exceed $40.00 per rentable square foot.