Press release -
Laser III is a prospective, randomized, non-inferiority trial conducted in the
Four-month recurrence-free survival was 8% higher after laser-ablation of the bladder tumor compared to TURBT, and the predefined noninferiority criterion was met. The study authors conclude that laser intervention in the outpatient setting is as good as TURBT with general anesthesia, and has less complications.
In addition, the paper also advocates the importance of enhanced cystoscopy to mediate this practice change. As recommended by the guidelines, enhanced cystoscopy should be used during surgical treatment of non-muscle invasive bladder cancer to improve detection and reduce recurrence.
"The study outcomes clearly demonstrate that for patients with small low grade stage Ta bladder tumors the procedure can be safely moved from the OR to the office, thereby reducing the burden for patients stemming from general anesthesia and cost related to hospital stays. Safety is the most important term here. Our team find that blue light cystoscopy with Hexvix in the OPD support the identification of small bladder tumors which therefore safely can be removed with laser before they become too large for outpatient treatment." said Dr. Gregers G Hermann, the Lead Investigator of this study and Consultant Urologist, MD, DM Sc, F.E.B.U.,
"We expect to see more scientific studies investigating how some of the more intensive procedures like TURBTs can be reduced, avoided, or made more bearable for patients. In non-muscle-invasive bladder cancer especially, where most patients are over 55 years old, research into reducing patient burden is of great importance. We believe BLC with Hexvix/Cysview can help responsible researchers in these efforts by minimizing the concern of uncertainty when it comes to detecting the tumors," said
Read the full publication here: https://www.sciencedirect.com/science/article/abs/pii/S0302283822025647
(Clinicaltrials.gov https://clinicaltrials.gov/ct2/show/NCT02886026)
*TURBT: Transurethral resection of bladder tumor
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About Bladder Cancer
Bladder cancer ranks as the 8th most common cancer worldwide - the 5th most common in men - with 1 720 000 prevalent cases (5-year prevalence rate)1a, 573 000 new cases and more than 200 000 deaths annually in 2020.1b
Approx. 75% of all bladder cancer cases occur in men.1 It has a high recurrence rate, with up to 61% in year one and up to 78% over five years.2 Bladder cancer has the highest lifetime treatment costs per patient of all cancers.3
Bladder cancer is a costly, potentially progressive disease for which patients have to undergo multiple cystoscopies due to the high risk of recurrence. There is an urgent need to improve both the diagnosis and the management of bladder cancer for the benefit of patients and healthcare systems alike.
Bladder cancer is classified into two types, non-muscle invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC), depending on the depth of invasion in the bladder wall. NMIBC remains in the inner layer of cells lining the bladder. These cancers are the most common (75%) of all cases and include the subtypes Ta, carcinoma in situ (CIS), and T1 lesions. In MIBC, the cancer has grown into deeper layers of the bladder wall. These cancers, including subtypes T2, T3, and T4, are more likely to spread and are harder to treat.4
1 Globocan. a) 5-year prevalence / b) incidence/mortality by population. Available at: https://gco.iarc.fr/today, accessed [January 2022].
2 Babjuk M, et al. Eur Urol. 2019; 76(5): 639-657
3 Sievert KD et al. World J Urol 2009;27:295-300
4 Bladder Cancer.
About Hexvix®/Cysview® (hexaminolevulinate HCl)
Hexvix/Cysview is a drug that preferentially accumulates in cancer cells in the bladder, making them glow bright pink during Blue Light Cystoscopy (BLC®). BLC with Hexvix/Cysview, compared to standard white light cystoscopy alone, improves the detection of tumors and leads to more complete resection, fewer residual tumors, and better management decisions.
Cysview is the tradename in the
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