SOTORASIB AT THE 2020 WORLD CONFERENCE ON LUNG CANCER

JANUARY 29, 2021

SAFE HARBOR STATEMENT

This presentation contains forward-looking statements that are based on the current expectations and beliefs of Amgen. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including any statements on the outcome, benefits and synergies of collaborations, or potential collaborations, with any other company, including BeiGene, Ltd. or any collaboration or potential collaboration in pursuit of therapeutic antibodies against COVID-19 (including statements regarding such collaboration's, or our own, ability to discover and develop fully-human neutralizing antibodies targeting SARS-CoV-2 or antibodies against targets other than the SARS-CoV-2 receptor binding domain, and/or to produce any such antibodies to potentially prevent or treat COVID-19), or the Otezla® (apremilast) acquisition (including anticipated Otezla sales growth and the timing of non-GAAP EPS accretion), as well as estimates of revenues, operating margins, capital expenditures, cash, other financial metrics, expected legal, arbitration, political, regulatory or clinical results or practices, customer and prescriber patterns or practices, reimbursement activities and outcomes, effects of pandemics or other widespread health problems such as the ongoing COVID-19 pandemic on our business, outcomes, progress, or effects relating to studies of Otezla as a potential treatment for COVID-19, and other such estimates and results. Forward-looking statements involve significant risks and uncertainties, including those discussed below and more fully described in the Securities and Exchange Commission reports filed by Amgen, including our most recent annual report on Form 10-K and any subsequent periodic reports on Form 10-Q and current reports on Form 8-K. Unless otherwise noted, Amgen is providing this information as of the date of this presentation and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise.

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Provided January 29, 2021, as part of an oral presentation and is qualified

by such, contains forward-looking statements, actual results may vary

2

materially; Amgen disclaims any duty to update.

INTRODUCTION

DAVID REESE, M.D.

EXECUTIVE VICE PRESIDENT, RESEARCH AND DEVELOPMENT

AGENDA

Introduction

David Reese, M.D.-Executive Vice President, Research and

Development

Sotorasib Phase 2

Gregory Friberg, M.D.-Vice President, Global Development and

NSCLC Update

Oncology Therapeutic Area Head

David Reese

Gregory Friberg

Q&A

Hossein Borghaei, D.O., M.S.-Professor and Chief,

Division of Thoracic Medical Oncology, Fox Chase Cancer Center,

Philadelphia, PA

Jurgen Wolf, M.D.-Professor and Medical Director, Center for

Integrated Oncology, University Hospital of Cologne, Germany

NSCLC = non-small cell lung cancer

Provided January 29, 2021, as part of an oral presentation and is qualified

by such, contains forward-looking statements, actual results may vary4 materially; Amgen disclaims any duty to update.

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Amgen Inc. published this content on 29 January 2021 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 30 January 2021 01:05:02 UTC.